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Viral pathogen discovery.
Viral pathogen discovery is of critical importance to clinical microbiology, infectious diseases, and public health. Genomic approaches for pathogen discovery, including consensus polymerase chain reaction (PCR), microarrays, and unbiased next-generation sequencing (NGS), have the capacity to comprehensively identify novel microbes present in clinical samples. Although numerous challenges remai...
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Discovery—literally, the act of uncovering—implies a new and fundamental observation that changes the way in which we view and respond to the world (Image 1). Eureka (‘‘I have found it’’) moments are rare in science. Given the physiques of many scientists, this may be a good thing. Legend has it that when Archimedes discovered while bathing that the volume of an object could be calculated by fi...
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Epidemics and pandemics caused by infectious pathogens have been a major cause of concern from the public health and economic point of view. The general approach in the past has been to investigate outbreaks in the shortest possible time using microbiological tools and initiate intervention strategies. However significant progress made in nucleic acid sequencing technologies and development of ...
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Discovery—literally, the act of uncovering—implies a new and fundamental observation that changes the way in which we view and respond to the world (Image 1). Eureka (‘‘I have found it’’) moments are rare in science. Given the physiques of many scientists, this may be a good thing. Legend has it that when Archimedes discovered while bathing that the volume of an object could be calculated by fi...
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The field of virus discovery has burgeoned with the advent of high throughput sequencing platforms and bioinformatics programs that enable rapid identification and molecular characterization of known and novel agents, investments in global microbial surveillance that include wildlife and domestic animals as well as humans, and recognition that viruses may be implicated in chronic as well as acu...
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ژورنال
عنوان ژورنال: Current Opinion in Microbiology
سال: 2013
ISSN: 1369-5274
DOI: 10.1016/j.mib.2013.05.001